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What causes diabetic nephropathy?

Hyperglycemia is a cause of diabetic nephropathy: diabetic nephropathy has a close relationship with high blood sugar, blood sugar in my hospital experts said the development of daily life and good control can accelerate the diabetic nephropathy, good blood glucose should be controlled effectively in daily life can significantly retard the development of. The increase of hyperglycemia and glycation end products cause mesangial cell proliferation, increased extracellular matrix and thickening of glomerular basement membrane. Ask patients to pay special attention to their daily routine.
Genetic factors: most diabetics do not end up with kidney disease. Experts say patients can also develop diabetic nephropathy in their daily lives if their blood sugar is well controlled. Glucose transporter -1 (GLUT1) is the major glucose transporter on glomerular mesangial cells, experts say. The difference of GLUT1 regulation and regulation between the inpidual mesangial cells of diabetic patients may be caused by kidney damage in some patients, which is one of the causes of diabetic nephropath
So on diabetic nephropathy should attach great importance to, as far as possible to achieve early diagnosis and early treatment, to prevent and delay the development of diabetic nephropathy and clinical manifestation, the main clinical manifestations of proteinuria, edema, hypertension, renal dysfunction. Albuminuria: Albuminuria is the first clinical manifestation of diabetic nephropathy, which is discontinuous at first and then persistent. Edema: because a large number of proteinuria can lead to edema in patients, once edema occurs, and has been developed to diabetic nephropathy later stage. Hypertension: Patients with hypertension appear late, one of the factors of high blood pressure is sodium retention. Because hypertension can aggravate the development of renal lesions and deterioration of renal function, attention should be paid to the control of hypertension. Abnormal renal function: if the patient is well controlled, he can develop proteinuria for many years without renal dysfunction. If the poor control, there will be nitrogen, blood, kidney dysfunction. In addition, diabetic nephropathy is often associated with diabetic retinopathy.

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