Sitemap | Make an Appointment | Email us: kidneyhope@yahoo.com | Hot line: 0086-15230187903

I Want To Find

Characteristic Therapy

Recommended reading

Popular tags reading

Patient Care

Kidney Disease

Healthy Information

What are the causes of diabetic nephropathy?

Diabetic nephropathy is a serious complication caused by diabetes for many years. It is one of secondary nephropathy. Because of the considerable harm of diabetic nephropathy, it is necessary to prevent it early. And only know the cause of diabetic nephropathy, in order to carry out targeted prevention. What are the causes of diabetic nephropathy?

Genetic factors: According to the statistics, there is a distinct difference in the incidence of diabetic nephropathy between different families, indicating that the onset of diabetic nephropathy is associated with genetic factors.

Hypertension: no significant relationship with the occurrence of diabetic nephropathy, but the elevated blood pressure during the period of hypertension or during the course of microalbuminuria can accelerate the progression of diabetic nephropathy and deterioration of renal function and aggravate the excretion of urinary albumin, which is also the cause of diabetic nephropathy.

Hyperglycemia: the incidence of diabetic nephropathy has non ignorable relationship with hyperglycemia, poor glycemic control can accelerate the onset of diabetic nephropathy, good control of blood sugar can obviously delay its development. Hyperglycemia and advanced glycation end products increased after mesangial cell proliferation, increased extracellular matrix, mesangial expansion, glomerular basement membrane thickening and so on.

High protein diet: patients with diabetes due to ingestion of restricted carbohydrate, high protein fiber in food supply, resulting in protein decomposition products of care for this and lose that load, and the excessive accumulation of phosphorus and, thus exacerbating the pathological damage of DN, thus become the etiology of diabetic nephropathy.

Glycated end product formation: diabetes patients failed to control blood sugar, long-term hyperglycemia can lead to increased production of glycation end products, glycation end products can cause extracellular matrix, such as type Ⅳ collagen, so that patients with glomerular synthesis of type Ⅳ collagen, , Mesangial and smooth muscle cell proliferation, thereby inducing diabetic nephropathy.

Renal blood flow abnormalities: in the onset of diabetic nephropathy, plays a key role, and may be the initial factor. High blood glucose, glomerular hypertransfusion, high filtration condition, increased transcapillary pressure, the expansion of mesangial cells, epithelial cell foot process fusion and produce the fine droplets, glomerular epithelial cells dropped from the basilar membrane. Glomerular basement membrane type Ⅳ collagen messenger sugar nucleic acid increased, so that the basement membrane thickening, and ultimately constitute the diffuse mesangial, nodular lesions, the onset of glomerular sclerosis. In the case of increased pressure, protein filtration can also accumulate in the mesangial region and the glomerular basement membrane, promote matrix hyperplasia, constitute a vicious cycle, and can cause nodular and diffuse glomerulosclerosis.

Diabetic nephropathy is a serious complication caused by diabetes for many years. It is one of secondary nephropathy. Because of the considerable harm of diabetic nephropathy, it is necessary to prevent it early. And only know the cause of diabetic nephropathy, in order to carry out targeted prevention. What are the causes of diabetic nephropathy?  Genetic factors: According to the statistics, there is a distinct difference in the incidence of diabetic nephropathy between different families, indicating that the onset of diabetic nephropathy is associated with genetic factors.  Hypertension: no significant relationship with the occurrence of diabetic nephropathy, but the elevated blood pressure during the period of hypertension or during the course of microalbuminuria can accelerate the progression of diabetic nephropathy and deterioration of renal function and aggravate the excretion of urinary albumin, which is also the cause of diabetic nephropathy.  Hyperglycemia: the incidence of diabetic nephropathy has non ignorable relationship with hyperglycemia, poor glycemic control can accelerate the onset of diabetic nephropathy, good control of blood sugar can obviously delay its development. Hyperglycemia and advanced glycation end products increased after mesangial cell proliferation, increased extracellular matrix, mesangial expansion, glomerular basement membrane thickening and so on.  High protein diet: patients with diabetes due to ingestion of restricted carbohydrate, high protein fiber in food supply, resulting in protein decomposition products of care for this and lose that load, and the excessive accumulation of phosphorus and, thus exacerbating the pathological damage of DN, thus become the etiology of diabetic nephropathy.  Glycated end product formation: diabetes patients failed to control blood sugar, long-term hyperglycemia can lead to increased production of glycation end products, glycation end products can cause extracellular matrix, such as type Ⅳ collagen, so that patients with glomerular synthesis of type Ⅳ collagen, , Mesangial and smooth muscle cell proliferation, thereby inducing diabetic nephropathy.  Renal blood flow abnormalities: in the onset of diabetic nephropathy, plays a key role, and may be the initial factor. High blood glucose, glomerular hypertransfusion, high filtration condition, increased transcapillary pressure, the expansion of mesangial cells, epithelial cell foot process fusion and produce the fine droplets, glomerular epithelial cells dropped from the basilar membrane. Glomerular basement membrane type Ⅳ collagen messenger sugar nucleic acid increased, so that the basement membrane thickening, and ultimately constitute the diffuse mesangial, nodular lesions, the onset of glomerular sclerosis. In the case of increased pressure, protein filtration can also accumulate in the mesangial region and the glomerular basement membrane, promote matrix hyperplasia, constitute a vicious cycle, and can cause nodular and diffuse glomerulosclerosis.

Request an Appointment at Kidney Service
Name:
Gender:
WhatsApp:
Email:
Phone:
Country:
Skype:
Description: