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What are the main risk factors for the progression of IgA nephropathy to chronic renal failure?
IgA nephropathy is the most common glomerular disease in the world, especially in Asian countries, which is the primary glomerular disease with IgA or IgA deposition in the glomerular Mesangial area. Its clinical manifestations are perse, the pathological situation is complex, and the prognosis is different. Therefore, understanding the risk factors affecting the prognosis of IgA nephropathy, for the establishment of IgA nephropathy treatment plan, delay the progress of the disease. It is particularly important to prevent the occurrence of adverse prognosis.
Proteinuria is one of the commonly accepted predictors of prognosis of IgA nephropathy. Many studies have used 24 hours urinary protein as an independent risk factor to influence the progression of the disease. One g / day was taken as the boundary of the severity of proteinuria.
Renal function is generally considered to represent the degree of renal injury, therefore, renal function is most correlated with prognosis.
Hypertension is a common complication in patients with IgA nephropathy. Thickening of the wall, narrowing of the lumen and secondary ischemic damage of renal parenchyma, especially malignant hypertension, can lead to malignant renal sclerosis of the middle and small arteries and rapidly enter into renal failure.
Hyperuricemia is a disorder of purine metabolism in the body. The renal damage is caused by the deposition of uric acid in renal tubulointerstitial. The level of uric acid affects the prognosis of renal disease. Hyperuricemia not only increases renal damage. It is closely related to hypertension and glycolipid metabolism, thus increasing the risk of cardiovascular and cerebrovascular diseases.
Glomerulosclerosis is a common result of the progression of renal damage caused by various causes. Glomerulosclerosis is an irreversible change, the higher the degree of glomerulosclerosis, the higher the risk of hypertension. The higher the risk of poor prognosis, the less residual renal units and the poorer renal function.
To sum up, there are many risk factors affecting IgA nephropathy, proteinuria, hypertension, high blood uric acid level. Glomerulosclerosis and interstitial fibrosis are traditionally recognized risk factors. IgA nephropathy as a chronic progressive disease, as early as possible to recognize and attach importance to risk factors, not only help doctors to formulate a reasonable treatment plan. Active intervention can also help patients understand the harm of disease and carry out scientific and standardized nursing measures. Doctors and patients cooperate closely and cooperate together. It is of great significance to delay the pathological process of IgA nephropathy and prevent the occurrence of poor prognosis.
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