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Can high blood pressure cause uremia?
For uremic patients, it is important to make clear the cause of the disease. In fact, many uremia are caused by high blood pressure, but many patients still have some doubts about this view. Here's how high blood pressure can cause uremia.
Hypertension is a disease characterized by elevated arterial pressure. Hypertension is closely related to uremia. If hypertension is not properly controlled, it can lead to kidney damage and even uremia. The long-term existence of hypertension can directly cause renal damage, that is, hypertensive nephropathy.
Hypertensive nephropathy at the early stage usually has no obvious symptoms. It may only be manifested as increased nocturia, which can be detected by mild proteinuria. Uremia is the development of hypertensive nephropathy to the end stage. Studies show that 15% of hypertensive patients develop uremia.
Hypertensive nephropathy includes hypertension, benign renal arteriolar sclerosis and hypertension, and malignant renal arteriolar sclerosis. Hardening of benign renal arterioles in hypertension refers to long-term hypertension leads to renal arteriolar hyalinization, and cause renal vascular ischemia and hypoxia, attracting inflammatory infiltration, cytokine release induced renal toxicity, which cause kidney damage and fibrosis; malignant hypertension and renal arteriosclerosis is due to diffuse lesions of renal arterioles rapid development of hypertension cause, lead to rapid deterioration of renal function.
The hardening of the interlobular arteries and glomeruli and the rapid progression of fibrosis may result in hypertension and uremia in a short period of time. The incidence of hypertensive renal damage is positively related to the severity of hypertension and the duration of hypertension. Other possible factors include smoking, alcohol abuse, gender, ethnicity, diabetes, hyperlipidemia, and hyperuricemia, which influence each other and further exacerbate kidney damage.
In addition, patients with renal dysfunction tend to rise in blood pressure, which leads to renal hypertension. The rise in blood pressure can, in turn, damage the kidneys and worsen kidney function. This vicious cycle is one of the important factors causing uremia in hypertensive nephropathy. In order to avoid and delay the occurrence of renal insufficiency, the blood pressure of patients with hypertension should be kept at an ideal level.