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Increased risk of chronic kidney disease in obese people by
March 9 is the twelfth World Kidney Day, this year's theme is kidney disease and obesity: a healthy lifestyle, a healthy kidney".
In 2014, the number of global obesity over the age of 18 is about 600 million, obesity has become a global epidemic. Obesity is a potential risk factor for kidney disease, chronic kidney disease (CKD) have direct and indirect effects. The risk factors of obesity increased slow nephropathy (type 2 diabetes, high blood pressure, heart disease). The risk, indirect effects of CKD; can also be based on increased kidney load mechanism causing direct damage to the kidney.
Thankfully, obesity and CKD can be prevented to a great extent. Through health education, so that the public understand the risk factors of obesity, maintaining a healthy lifestyle (such as eating a balanced diet, moderate exercise), can effectively prevent obesity and kidney disease.
On the arrival of the 2017 World Kidney day, "Nature Reviews Nephrology" magazine interviewed five experts from the United States, China, Brazil and Japan four countries, including Liu Zhighong academician, from Nanjing General Hospital of Nanjing Military Region.
Liu Zhihong: Obesity-related glomerular disease incidence is 10 times higher than 10 years ago.
Liu Zhighong academician pointed out that 50% of patients with type 2 diabetes will develop into CKD, obese people CKD risk increased by 23%. In addition, obesity is also a risk factor for kidney stones and cancer (including kidney cancer). Diabetes and obesity further affect CKD progression and prognosis.
Over the past 30 years, the incidence of diabetes-related CKD has increased dramatically. In 2016, a survey showed that diabetes-related CKD had exceeded glomerulonephritis in China, and glomerulonephritis was once the most important for end-stage renal disease (ESRD) in China Etiology.
In addition, a US data showed that obesity-related glomerular disease (ORG) incidence is 10 times higher than 10 years ago, 1986 to 1990 was 0.2%, 1996-2000 2.0%. Another study showed that the risk of ESRD was increased three-fold in patients with a body mass index> 30 kg / m2.
Liu Zhihong academician said that based on the pathologic basis of obesity-related nephropathy, RAAS blockers and weight loss (controlled diet and weight loss surgery) are two major means of delaying obesity-related nephropathy. ACEI and ARB reduce proteinuria and reduce the incidence of ESRD in ORG patients. Lifestyle intervention (exercise, balanced nutrition, improve bad behavior, etc.) is the first line of prevention and control of obesity.
As obesity is usually associated with some non-infectious diseases at the same time, so pay attention to the complications of ORG patients. The management of ORG patients requires the joint efforts of a multidisciplinary team of Nephrology experts, diabetes experts, heart specialists, nutritionists, etc.
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