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What is the knowledge we need to know of pregnancy in patients with chronic kidney disease?

Situations suitable for pregnancy: In the early stages of CKD (stage 1-2), if the blood pressure is normal, urinary protein <1g / 24h for at least six months may be considered for pregnancy, but the risk of pregnancy is still high.

Not suitable for pregnancy

CKD stage 3-5 patients, mid-late CKD women during pregnancy may face serious complications such as anemia, acidosis, hyperphosphatemia and bone disease. High blood pressure is difficult to control, of course, if take positive drug treatment, blood pressure re-evaluation of the standard, the back can also be considered pregnant. Uncontrolled proteinuria, especially in patients with large amounts of proteinuria, are prompted renal disease in the active state, the active treatment of nephropathy is the most important thing. Active lupus nephritis, it is recommended until the disease treatment to achieve complete remission or stable condition near complete remission for at least 6 months. Moderate to severe renal impairment in patients with diabetic nephropathy, mainly because of pregnancy will accelerate the decline in renal function and will rapidly progress to a large number of proteinuria, so do not recommend pregnancy.

What is the knowledge we need to know of pregnancy in patients with chronic kidney disease?

Dialysis and kidney transplant patients are suitable for pregnancy? Dialysis patients are not recommended for pregnancy, of course, there is a successful precedent in the world, but the risk is too great. Relatively speaking, the successful renal transplantation patients, under the guidance of the physician, based on the condition and treatment, can be elective pregnancy, but the risk of pregnancy is relatively high.

What do we need to pay attention to when preparing pregnancy?

First, if the disease has a tendency to ameliorate and improve, you need to use drugs that are safe during pregnancy within 3 to 6 months prior to trying to conceive, and the female reproductive system and the drugs that can cause fetal malformations need to be stopped or not eaten. For example, cyclophosphamide this drug will directly cause ovarian damage, so for women of childbearing age to avoid using. Mycophenolate mofetil, leflunomide and methotrexate have teratogenic effects, should be discontinued at least 3 to 6 months before conception. Also, it is necessary to strict contraception before the disease remission.

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